| 6-氯-1-茚酮的合成 |
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| 引用本文： | 张桂玲,罗绪强. 6-氯-1-茚酮的合成[J]. 化学研究, 2010, 21(3): 51-53 |
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| 作者姓名： | 张桂玲 罗绪强 |
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| 作者单位： | 贵阳学院,化学与材料科学系,贵州,贵阳,550003;贵州师范学院,地理与旅游学院,贵州,贵阳,550018;贵州师范学院,资源环境与灾害研究所,贵州,贵阳,550018 |
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| 基金项目： | 贵州省科学技术基金,贵州省教育厅自然科学基金 |
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| 摘 要： | 以对氯氯苄和丙二酸二乙酯为原料,经缩合、碱性水解、脱羧、酰氯化、Friedel-Crafts酰基化等反应得到6-氯-1-茚酮,总收率62%,纯度99%.其结构经核磁共振谱(1H NMR)、质谱(MS)和元素分析确认.
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| 关 键 词： | 茚酮 Friedel-Crafts反应 缩合 合成 |
Synthesis of 6-Chloro-1-indanone |
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| ZHANG Gui-ling,LUO Xu-qiang. Synthesis of 6-Chloro-1-indanone[J]. Chemical Research, 2010, 21(3): 51-53 |
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| Authors: | ZHANG Gui-ling LUO Xu-qiang |
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| Affiliation: | 1.Department of Chemistry and Material Science,Guiyang University,Guiyang 550003,Guizhou,China;2.School of Geography and Tourism,Guizhou Normal College,Guiyang 550018,Guizhou,China;3.Institute for Resources Environment and Disaster,Guizhou Normal College,Guiyang 550018,Guizhou,China) |
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| Abstract: | 4-Chlorobenzyl chloride and diethyl malonate were used as the starting materials to synthesize 6-chloro-1-indanone via condensation,alkaline hydrolysis,decarboxylation,acyl chlorination,and Friedel-Crafts acylation reaction.The target product was obtained at a total yield of 62% and with a purity of 99%.Moreover,the structure of the product was characte-rized by means of 1H-nuclur magnetic resonance spectrometry,mass spectrometry,and elemental analysis. |
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| Keywords: | indanone Friedel-Crafts acylation reaction condensation synthesis |
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