BINOLAM,a recoverable chiral ligand for bifunctional enantioselective catalysis: the asymmetric synthesis of cyanohydrins |
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| Authors: | Casas Jesús Nájera Carmen Sansano José M Saá José M |
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| Affiliation: | Departamento de Química Orgánica, Universidad de Alicante, Apartado 99, 03080-Alicante, Spain. |
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| Abstract: | [reaction: see text] A new bifunctional catalytic system based on a monometallic aluminum complex is used for the efficient enantioselective cyanation of aldehydes. The ligand (S)- or (R)-2,2'-bis(diethylaminomethyl)-substituted binaphthol (BINOLAM) used is recovered for recycling. This methodology is used for the synthesis of a precursor of epothilone A. |
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