A new route to sulfonamides via intermolecular radical addition to pentafluorophenyl vinylsulfonate and subsequent aminolysis |
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| Authors: | Caddick Stephen Wilden Jonathan D Bush Hannah D Wadman Sjoerd N Judd Duncan B |
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| Institution: | Centre for Biomolecular Design and Drug Development, University of Sussex, Falmer, Brighton BN1 9QJ, UK. s.caddick@sussex.ac.uk |
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| Abstract: | reaction: see text] Various radical species generated from either the corresponding iodo- or bromo- compounds and tri-n-butyltin hydride were added in an intermolecular fashion to the activated acceptor pentafluorophenyl vinylsulfonate. The products of each reaction were then subjected to aminolysis with a variety of different amines. |
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