Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties |
| |
| Authors: | García-Moreno M Isabel Díaz-Pérez Paula Ortiz Mellet Carmen García Fernández José M |
| |
| Affiliation: | Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, E-41071 Sevilla, Spain. |
| |
| Abstract: | Bicyclic azasugar glycomimetics related to castanospermine and trehazolin have been prepared from sugar carbodiimides via aminooxazoline intermediates; preliminary enzyme inhibition tests showed a marked dependence of the selectivity and potency towards alpha and beta-glucosidases upon the nature of the exocyclic substituent. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
