Electron capture dissociation and collision-induced dissociation of metal ion (Ag+, Cu2+, Zn2+, Fe2+, and Fe3+) complexes of polyamidoamine (PAMAM) dendrimers |
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Authors: | Malgorzata A Kaczorowska Helen J Cooper |
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Institution: | 1. School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
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Abstract: | The electron capture dissociation (ECD) and collision-induced dissociation (CID) of complexes of polyamidoamine (PAMAM) dendrimers
with metal ions Ag+, Cu2+, Zn2+, Fe2+, and Fe3+ were determined by Fourier transform ion cyclotron resonance mass spectrometry. Complexes were of the form PD + M + mH]5+ where PD = generation two PAMAM dendrimer with amidoethanol surface groups, M = metal ion, m = 2−4. Complementary information
regarding the site and coordination chemistry of the metal ions can be obtained from the two techniques. The results suggest
that complexes of Fe3+ and Cu2+ are coordinated via both core tertiary amines, whereas coordination of Ag+ involves a single core tertiary amine. The Zn2+ and Fe2+ complexes do not appear to involve coordination by the dendrimer core. |
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