Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes |
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| Authors: | Tameryn StringerDenver T Hendricks Hajira GuzgayGregory S Smith |
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| Institution: | a Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, Cape Town, South Africa
b Division of Medical Biochemistry, University of Cape Town, Rondebosch 7701, Cape Town, South Africa |
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| Abstract: | A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C{1H} and 31P{1H}) spectroscopy. The data revealed tridentate (O-N-S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity. |
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| Keywords: | Salicylaldimine Multimeric thiosemicarbazones Palladium Platinum |
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