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Synthesis, structural and spectral studies of Cu(II) and V(IV) complexes of a novel Schiff base derived from pyridoxal. Antimicrobial activity |
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| Authors: | Tudor Rosu Elena PahontuMezey Reka-Stefana Diana-Carolina Ilies Rodica GeorgescuSergiu Shova Aurelian Gulea |
| Affiliation: | a Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 050107 Bucharest, Romania b Organic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Street, 020956 Bucharest, Romania c Nuclear Physics and Engineering Institute “Horia Hulubei”, Bucharest, Romania d “Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Vod_a 41A, RO-700487 Iasi, Romania e Coordination Chemistry Department, Moldova State University, Chisinau, Republic of Moldova |
| Abstract: | A novel Schiff base, N-(4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one)pyridoxaldimine (HL·HCl), was prepared and structurally characterized on the basis of elemental analyses, 1H and 13C NMR, and IR spectral data. The synthesis and characterization of several Cu(II) (1-6) and V(IV) (7) complexes with N-(4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one)pyridoxaldimine are reported. The composition and structures of the copper(II) and vanadium(IV) complexes were proposed based on elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic and EPR spectroscopy. In addition, the structures of the ligand and the complex [CuL(H2O)2]NO3·2.25H2O (1) have been determined by single-crystal X-ray diffraction, showing that the Cu(II) center has a distorted square-pyramidal geometry. The ligand and the complexes were also tested for their in vitro antibacterial activity. |
| Keywords: | Copper(II) complexes Vanadium(IV) complex Schiff base Antimicrobial activity N-(4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one)pyridoxaldimine 1-Phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-one Crystal structure Pyridoxal hydrochloride |
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