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Synthesis, structure, electrochemical properties, cytotoxic effects and antioxidant activity of 5-amino-8-methyl-4H-benzopyran-4-one and its copper(II) complexes |
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| Authors: | Magdalena Gra?ulAleksander Kufelnicki,Magdalena WozniczkaIngo-Peter Lorenz,Peter MayerAndrzej Jó ?wiak,Malgorzata CzyzElzbieta Budzisz |
| Affiliation: | a Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland b Department of Physical and Biocoordination Chemistry, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland c Department of Chemistry, Ludwig Maximilians University, Butenandtstr. 5-13 (D), D-81377 Munich, Germany d Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland e Department of Molecular Biology of Cancer, Medical University of Lodz, Mazowiecka 6/8 Street, 92-215 Lodz, Poland |
| Abstract: | The chromone derivative 5-amino-8-methyl-4H-benzopyran-4-one (ligand) (1) has been used to obtain a series of Cu(II) complexes 2-4 as potential anticancer compounds. The molecular structures of ligand 1 and its Cu(II) complex 3 have been determined by X-ray crystallography. The cytotoxicity of all obtained compounds has been evaluated on melanoma A375 cell line. The ability of compounds 1-4 to take part in redox reactions and their antioxidant activity have been studied. |
| Keywords: | DMSO, dimethyl sulfoxide DMF, N,N-dimethylformamide ABTS, 2,2&prime -azinobis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide |
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