Physico-chemical changes taking place in gamma irradiated bovine globulins studied by thermal analysis |
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Authors: | Krystyna Cieśla Etienne F Vansant |
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Institution: | (1) Institute of Nuclear Chemistry and Technology, Dorodna 16 str., 03-195 Warszawa, Poland;(2) Department of Chemistry, University of Antwerp, Universiteitplein, 2610 Wilrijk, Belgium |
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Abstract: | Structural transformations induced in gamma and alpha globulins under influence of gamma irradiation using doses of 2.5 and
24 kGy were studied by differential scanning calorimetry (DSC) and thermogravimetry (TG, DTG). Thermal decomposition of the
globulins irradiated in water suspensions occurs at higher temperatures, in comparison to the reference non-irradiated samples.
This was related to formation of covalent linkages in the irradiated proteins, apart to chemical changes induced in amino-acids.
Essential modification of thermal decomposition was detected already after irradiation with a dose of 2.5 kGy performed for
water suspensions. Irradiation of solid native proteins induces decrease in decomposition temperature and gives evidence of
proteins degradation. |
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