Recent advances on small-molecule fluorophores with emission beyond 1000 nm for better molecular imaging in vivo |
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| Authors: | Le Tu Yuling Xu Qingying Ouyang Xiangyang Li Yao Sun |
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| Institution: | 1. College of Chemistry, China University of Petroleum, Qingdao 266555, China;2. International Joint Research Center for Intelligent Biosensor Technology and Health, Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China;3. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China |
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| Abstract: | In the second near-infrared channel (NIR-II, 1000–1700 nm), organic and inorganic fluorophores are designed with superior chemical/optical properties to provide real-time information with deeper penetration depth and higher resolution owing to the innate lower light scattering and absorption of the NIR-II imaging than conventional optical imaging. Among them, the small-molecule based fluorophores have been highlighted due to their desirable biocompatibility and favorable pharmacokinetics. In this review, we introduced the latest research progress of the rational design of small-molecule NIR-II fluorophores and their impressively biological applications including the NIR-II signal imaging, multimodal imaging and theranostic. |
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| Keywords: | Corresponding authors Small-molecule fluorophores The second near-infrared channel Benzo-bisthiadiazole Biomedical imaging |
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