| Synthesis and Chiral Separation of Dinucleotide（TpAZT） Phosphoramidates |
| |
| 引用本文： | ChangXueLIN HuaFU GuangZhongTU YuFenZHAO. Synthesis and Chiral Separation of Dinucleotide（TpAZT） Phosphoramidates[J]. 中国化学快报, 2003, 14(8): 779-782 |
| |
| 作者姓名： | ChangXueLIN HuaFU GuangZhongTU YuFenZHAO |
| |
| 作者单位： | [1]KeyLaboratoryofBioorganicPhosphorusChemistry,MinistryofEducation,DepartmentofChemistry,SchoolofLifeSciencesandEngineering.TsinghuaUniversity.Beijing100084 [2]BeijingInstituteofMicrochemistry,Beijing100091 |
| |
| 基金项目： | 国家自然科学基金，科技部资助项目 |
| |
| 摘 要： | Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Sp) were separated by crystallization, and the results showed that natural and cheap methyl esters of alanine and phenylalanine can be used for large-scale synthesis of dinucleotide analogs.
|
| 关 键 词： | 合成 手性助剂 手性分离 二核苷酸氨基磷酸酯 托德反应 氨基酸甲基酯 结晶化 药物 AIDS 临床诊断 |
Synthesis and Chiral Separation of Dinucleotide(TpAZT) Phosphoramidates |
| |
| Chang Xue LIN,Hua FU,Guang Zhong TU,Yu Fen ZHAO. Synthesis and Chiral Separation of Dinucleotide(TpAZT) Phosphoramidates[J]. Chinese Chemical Letters, 2003, 14(8): 779-782 |
| |
| Authors: | Chang Xue LIN Hua FU Guang Zhong TU Yu Fen ZHAO |
| |
| Abstract: | Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Sp) were separated by crystallization, and the results showed that natural and cheap methyl esters of alanine and phenylalanine can be used for large-scale synthesis of dinucleotide analogs. |
| |
| Keywords: | Dinucleotide phosphoramidate chiral auxiliary chiral separation. |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
