Collaborative trial validation study of two methods, one based on high performance liquid chromatography-tandem mass spectrometry and on gas chromatography-mass spectrometry for the determination of acrylamide in bakery and potato products |
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Authors: | Wenzl Thomas Karasek Lubomir Rosen Johan Hellenaes Karl-Erik Crews Colin Castle Laurence Anklam Elke |
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Affiliation: | European Commission - Joint Research Centre - Institute for Reference Materials and Measurements, Retieseweg 111, 2400 Geel, Belgium. thomas.wenzl@ec.europa.eu |
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Abstract: | A European inter-laboratory study was conducted to validate two analytical procedures for the determination of acrylamide in bakery ware (crispbreads, biscuits) and potato products (chips), within a concentration range from about 20 microg/kg to about 9000 microgg/kg. The methods are based on gas chromatography-mass spectrometry (GC-MS) of the derivatised analyte and on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) of native acrylamide. Isotope dilution with isotopically labelled acrylamide was an integral part of both methods. The study was evaluated according to internationally accepted guidelines. The performance of the HPLC-MS/MS method was found to be superior to that of the GC-MS method and to be fit-for-the-purpose. |
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