Solid-phase synthesis of constrained terminal and internal lactam peptidomimetics |
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| Authors: | Scott William L Alsina Jordi Kennedy Joseph H O'Donnell Martin J |
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| Institution: | Department of Chemistry, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA. wscott@chem.iupui.edu |
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| Abstract: | Lactams are key components of many peptidomimetic structures. Five- and six-membered lactam peptidomimetics with hydrogen or amino acid side chains at the alpha-position can be constructed from peptide precursors during a solid-phase synthesis. There is no significant racemization of remote stereocenters during synthesis. |
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