离子液体中卤素交换氟化合成七氟醚

在离子液体作为反应介质的条件下,以六氟异丙基氯甲基醚的氟代反应合成了七氟醚。 探讨了氟代反应机理,考察了bpy]BF4、bmim]BF4、bepy]BF4、bmim]PF6对反应产率的影响，研究了氟化剂、水和温度对反应产率的影响。 结果表明,以bepy]BF4为反应介质,高比表面积的KF和微量的水有利于固态KF的部分离解进入有机相形成高活性的F-从而减少副产物,收率达到94.6%。 离子液体可重复使用3次以上，其活性没有明显下降。

Synthesis of sevoflurane changed by halogen-exchange fluorination in Ionic Liquids

Sevoflurane was synthesized from 1,1,13,3,3-hexafluoro-2-(chloromethoxy)-propane by halogen-exchange in the presence of an ionic liquid as the solvent and a fluorinating agent . Mechanism of the phase transfer catalysis was discussed. The effects of bpy]BF4, bmim]BF4, bepy]BF4 and bmim]PF6 on the yield were investigated. The ionic liquid water system and high surface area could not only induce KF to enter into the ionic liquid to produce high active F- but also reduce the formation of byproducts. The yield was 94.6％. The ionic liquid could be reused for three times without noticeable loss of activity.