Ion-interaction chromatography of neutral molecules |
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Authors: | T Cecchi F Pucciarelli P Passamonti |
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Institution: | (1) Dipartimento di Scienze Chimiche, Università degli Studi di Camerino, Via S. Agostino 1, 62032 Camerino, Italy |
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Abstract: | Summary The chromatographic behavior of neutral molecules in ion-interaction chromatography (IIC) is investigated theoretically. The
physical and chemical modification of the stationary phase in the presence of ion interaction Reagent (IIR) in the eluent,
and adsorption competition between test analytes and IIR for inner layer sites are shown theoretically to change the partition
coefficient of neutral molecules.
The most reliable, literature experimental results, concerming retention behaviour of neutral molecules in IIC, were used
to test the new theory. The wide variability among them was elucidated on the basis of the exhaustive retention model developed.
Retention equations were compared to those which can be obtained, if the change of the analyte is zero, from the most important
retention model in IIC. |
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Keywords: | Column liquid chromatography Ion interaction chromatography Neutral analyte Retention equation |
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