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Formal synthesis of nitidine through palladium-catalyzed isocoumarin synthesis |
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| Authors: | Tatsuya Minami Akemi Nishimoto Miyoji Hanaoka |
| Institution: | Faculty of Pharmaceutical Sciences, Kanazawa University,13-1 Takara-machi, Kanazawa 920, Japan |
| Abstract: | The isoquinolone intermediate 9 for the synthesis of nitidine was synthesized through palladium-catalyzed formation of isocoumarin 7 from o-styrylbenzoic acid derivative 5, which was prepared from palladium-catalyzed coupling reactions of aryl iodide 1 and 2 with vinylsilane. |
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