DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles |
| |
| Authors: | Pramanik Smritimoy Nagatoishi Satoru Sugimoto Naoki |
| |
| Institution: | Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe 650-0047, Japan. |
| |
| Abstract: | In an equimolar ratio the human telomeric oligonucleotides dAGGG(TTAGGG)(3)] and d(CCCTAA)(3)CCCT] formed mixed structures of duplex and tetraplex in bis(2-ethylhexyl)sulfosuccinate reverse micelles; only the duplex was observed in aqueous buffer. This finding suggests that heterogeneous confined media in the cell nucleus might induce a significant fraction of the telomeric region of genomic DNA to adopt non-canonical tetraplex structure. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
