Regioselective Cu(I)-catalyzed tandem A3-coupling/decarboxylative coupling to 3-amino-1,4-enynes |
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| Authors: | Feng Huangdi Ermolat'ev Denis S Song Gonghua Van der Eycken Erik V |
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| Affiliation: | Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemstry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium. |
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| Abstract: | An efficient and novel copper-mediated protocol for the synthesis of 3-amino-1,4-enynes from glyoxylic acid, an amine, and an alkyne was developed. This new reaction involving two sequential C-C bond formations is air and moisture tolerant and proceeds via a tandem A(3)-coupling and a selective decarboxylative coupling. |
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