TGF-β1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors |
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| Authors: | Alick KT Law Deepak Gupta Shawn Levy Douglas C Wallace Robert J McKeon Charles R Buck |
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| Affiliation: | (1) Department of Physiology, Emory University, Atlanta, USA;(2) The Center for Molecular Medicine, Emory University, Atlanta, USA;(3) Department of Cell Biology, Emory University, Atlanta, USA;(4) Oridis Biomed, Graz, Austria |
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| Abstract: | Background The adenine nucleotide translocator 1 (Ant1) is an inner mitochondrial membrane protein involved with energy mobilization during oxidative phosphorylation. We recently showed that rodent Ant1 is upregulated by transforming growth factor-beta (TGF-β) in reactive astrocytes following CNS injury. In the present study, we describe the molecular mechanisms by which TGF-β1 regulates Ant1 gene expression in cultured primary rodent astrocytes. |
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