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o-Quinone methide based approach to isoflavans: application to the total syntheses of equol, 3′-hydroxyequol and vestitol |
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| Authors: | Santosh J Gharpure AM Sathiyanarayanan Prasad Jonnalagadda |
| Institution: | Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India |
| Abstract: | A concise strategy is developed for the synthesis of isoflavans employing a Diels-Alder reaction between o-quinone methides and aryl-substituted enol ethers followed by reductive cleavage of the acetal group. The method is extended towards the total syntheses of equol, 3′-hydroxyequol and vestitol. |
| Keywords: | o-Quinone methides Diels-Alder reaction Isoflavonoids Equol Hydroxyequol Vestitol |
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