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Nucleoside derived amino acids (NDA) in foldamer chemistry: synthesis and conformational studies of homooligomers of modified AZT |
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| Authors: | S Chandrasekhar G Pavan Kumar Reddy Ch Nagesh |
| Institution: | a Division of Organic Chemical Sciences, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500 007, India b Centre for Nuclear Magnetic Resonance, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500 007, India |
| Abstract: | Homo short-oligomers of a novel trans-β-amino acid derived from AZT were synthesized and characterized. These adopt right-handed helical turns with their bases positioned systematically along the helix axis. These studies open up new possibilities for synthesizing nucleoside derived functional foldamers. |
| Keywords: | Trans-β-amino acid AZT Oligonucleoside NMR Helical turn |
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