| 吡咯-多胺钴配合物的合成及与DNA的作用研究 |
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| 引用本文： | 周春琼,邹 敏,游文玮,唐中坤,郭瑞芬. 吡咯-多胺钴配合物的合成及与DNA的作用研究[J]. 无机化学学报, 2010, 26(2): 257-262 |
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| 作者姓名： | 周春琼 邹 敏 游文玮 唐中坤 郭瑞芬 |
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| 作者单位： | 南方医科大学药学院,广州,510515 |
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| 摘 要： | 合成了一种新的钴配合物[CoL(CH3CH2OH)Cl]Cl,L为N1,N8-二(1-甲基-4-硝基吡咯-2-酰基)三乙基四胺,并用质谱、核磁、红外、摩尔电导、元素分析等多种手段分析了配体和配合物的结构;紫外、荧光和粘度等方法分析了钴配合物与小牛胸腺DNA的作用,发现配合物与DNA的作用方式可能为部分插入和静电混合作用模式;电泳法研究了配合物与超螺旋pBR322DNA的作用,发现反应温度为50℃时,配合物能将超螺旋DNA完全切割为缺刻产物。
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| 关 键 词： | 吡咯； 多胺； 钴配合物； DNA |
Synthesis, DNA-Binding and Cleavage Studies by Cobalt Complex of Pyrrole-Multiamine |
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| ZHOU Chun-Qiong,ZOU Min,YOU Wen-Wei,TANG Zhong-Kun and GUO Rui-Fen. Synthesis, DNA-Binding and Cleavage Studies by Cobalt Complex of Pyrrole-Multiamine[J]. Chinese Journal of Inorganic Chemistry, 2010, 26(2): 257-262 |
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| Authors: | ZHOU Chun-Qiong ZOU Min YOU Wen-Wei TANG Zhong-Kun GUO Rui-Fen |
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| Affiliation: | School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515,School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515,School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515,School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 |
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| Abstract: | A new cobalt complexCoL(CH3CH2OH)ClCl(L=N1,N8-bis(1-methyl-4-nitropyrrole-2-carbonyl) triethylenetetramine) was synthesized.Its structure was characterized by MS,1H NMR,IR,molar conductance and elementary analysis.CT DNA-binding of cobalt complex was investigated using UV spectra,fluorescent spectra and viscosity.The results indicate that the cobalt complex may interact with CT DNA by partial intercalation and electroscope binding.The cleavage reaction on plasmid DNA was monitored by agarose gel electrophor... |
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| Keywords: | pyrrole multiamine cobalt complex DNA |
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