Synthesis and in vitro activity of 6-amino-2,9-diarylpurines for Mycobacterium tuberculosis |
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Authors: | Carla Correia M Fernanda Proença |
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Institution: | Departamento de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal |
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Abstract: | A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new compounds were screened for antibacterial activity against Mycobacterium tuberculosis strain H37Rv. The 9-tolyl derivatives with a dimethylamino or a piperidine substituent in C6 and the 3-hydroxyphenyl or 4-hydroxyphenyl substituent in C2 were highly active against the bacilli. |
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Keywords: | Purine Antimicrobial agent Tuberculosis |
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