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Ring opening of cyclic N,O-acetals with allyltrimethylsilane under Lewis acidic conditions
Authors:Roderick W. Bates  Yongna Lu  Melody Peiling Cai
Affiliation:Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, 21 Nanyang Link, Nanyang Technological University, Singapore 637371
Abstract:Five and six-membered cyclic N,O-acetals with N-carboxyalkyl and sulfonyl groups undergo clean and high yielding ring opening with allyltrimethylsilane in the presence of strong Lewis acids to give homoallylic amine derivatives.
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