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Synthesis of undecaprenyl pyrophosphate-linked glycans as donor substrates for bacterial protein N-glycosylation
Authors:Yong Joo Lee
Institution:RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Abstract:Synthesis of undecaprenyl pyrophosphate (Und-PP)-linked glycans is described. Bacterial (E]3,Z]7)-undecaprenol was synthesized from trans-geranylgeranyl sulfone and isoprenoid building blocks, which was converted to undecaprenyl phosphate (Und-P). It was coupled with glycosyl phosphates to afford Und-PP-linked glycans, including core trisaccharide of Campylobacter jejuni N-glycan. Our synthetic method for Und-PP-linked glycan would provide various substrates as a useful tool for systematic analysis of bacterial protein N-glycosylation.
Keywords:Undecaprenol  Glycosyl phosphate  Und-PP-linked glycan  N-Glycosylation
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