Novel cyclopeptide and unique flavone from Desmos rostrata. Total synthesis of desmorostratone |
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Authors: | Ngoc Tuan Nguyen Marc Litaudon Bernard Bodo Van Hung Nguyen |
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Institution: | a Institute of Chemistry—Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Viet Nam b Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette cedex, France c Laboratoire de Chimie et Biochimie des Substances Naturelles—CNRS, Muséum National d'Histoire Naturelle, 63 rue Buffon, 75005 Paris, France |
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Abstract: | Two new compounds, a cyclic peptide desmocyclopeptide (1) and a special flavone desmorostratone (2) were isolated from the stem bark of Desmos rostrata, along with two known compounds, desmosdumotins B (3) and C (4). Their structures were established on the basis of the spectral data, including mass spectrometry and 2D NMR. The total synthesis of desmorostratone (2) was performed in order to confirm its structure as well as that of desmosdumotin C (4), which was a tautomeric mixture in the solution. Finally, cytotoxity of these compounds were evaluated. Desmosdumotin C (4) displayed a moderate inhibition activity against KB cell line with an IC50 of 19.2 μM, whereas the other products showed a weak inhibition against the same cell line target. |
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