Palladium-catalyzed three-component transformation of homoallenols: a regio- and stereoselective route to 1,5-amino alcohols |
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Authors: | Aylward Miriam Coeffard Vincent Guiry Patrick J |
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Affiliation: | Centre for Synthesis and Chemical Biology (CSCB), School of Chemistry and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. |
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Abstract: | A palladium-catalyzed three-component transformation of enantioenriched homoallenols with aryl halides and amines has been developed to selectively afford (Z)-configured 1,5-amino alcohols in good-to-excellent yields without any epimerization. |
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