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Vibrational study of tamoxifen citrate polymorphism |
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| Authors: | MC Gamberini C Baraldi A Tinti F Palazzoli V Ferioli |
| Institution: | aDepartment of Pharmaceutical Sciences, Institute of Pharmacy, University of Modena and Reggio Emilia, via Campi n.183, 41100 Modena, Italy bDepartment of Biochemistry, University of Bologna, via Belmeloro 8/2, 40126 Bologna, Italy |
| Abstract: | The trans isomer of (Z)-2-p-(1,2-diphenyl-butenyl)phenoxy]-N,N-dimethyletylamine (tamoxifen) is well known for its endocrine activity as an antiestrogenic agent. Its citrate salt, a widely used pharmaceutical agent, appears in three main polymorphic forms, two of which are well known (I and II) and another form not yet well evidenced. A vibrational study has been conducted for identifying the two known polymorphic forms of tamoxifen citrate (I and II) and for characterising the other form (form III) examined in this study. Other techniques for the characterization of the different polymorphs, such as XRDP, have been used. |
| Keywords: | Tamoxifen citrate polymorphism Raman spectroscopy (Raman Microscopy Hot-stage Raman microscopy) IR spectroscopy (ATR/FT-IR) X-ray powder diffraction (XRPD) Solid state properties Vibrational study |
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