| Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives |
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| 引用本文： | Xue Fei Yang Ling Yi Kong. Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives[J]. 中国化学快报, 2007, 18(4): 380-382. DOI: 10.1016/j.cclet.2007.01.018 |
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| 作者姓名： | Xue Fei Yang Ling Yi Kong |
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| 作者单位： | Xue Fei Yang，Ling Yi Kong* Department of Natural Medicinal Chemistry，China Pharmaceutical University，Nanjing 210009，China |
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| 基金项目： | The authors are grateful to Xiaoming Jia of the National Laboratory for Drug Screening and Jiangsu Center for Drug Screening, for cytotoxicity screening and Prof. Daqi Wang of Liaocheng University, for X-ray measurement. |
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| 摘 要： | A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3-methoxy-4-hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step.The structures of the new compounds were confirmed by1H NMR,IR and MS.The structure of compound 14 was further confirmed by single crystal X-ray.Compound 17 showed cytotoxic activity against human lung carcinoma A549.
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| 关 键 词： | 2-芳基-5-烷基-7-甲氧苯并[b]呋喃 衍生物 合成 新木脂体 细胞毒性 |
| 收稿时间： | 2006-08-31 |
Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives |
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| Xue Fei Yan,Ling Yi Kong. Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives[J]. Chinese Chemical Letters, 2007, 18(4): 380-382. DOI: 10.1016/j.cclet.2007.01.018 |
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| Authors: | Xue Fei Yan Ling Yi Kong |
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| Affiliation: | Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3-methoxy-4-hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step.The structures of the new compounds were confirmed by1H NMR,IR and MS.The structure of compound 14 was further confirmed by single crystal X-ray.Compound 17 showed cytotoxic activity against human lung carcinoma A549. |
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| Keywords: | 2-Aryl-5-alkyl-7-methoxylbenzo[b]furan Neolignans Synthesis Cytotoxicity |
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