Efficient iron(III)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines |
| |
Authors: | Gao Jian Song Qing-Wen He Liang-Nian Yang Zhen-Zhen Dou Xiao-Yong |
| |
Affiliation: | State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China. |
| |
Abstract: | An iron(III)-catalyzed three-component coupling reaction of alkynes, CH(2)Cl(2) and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl(3) and 1,1,3,3-tetramethylguanidine. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|