Intramolecular folding in three tandem guanine repeats of human telomeric DNA |
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| Authors: | Koirala Deepak Mashimo Tomoko Sannohe Yuta Yu Zhongbo Mao Hanbin Sugiyama Hiroshi |
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| Affiliation: | Department of Chemistry & Biochemistry, Kent State University, Kent, OH 44242, USA. |
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| Abstract: | Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem guanine repeats. |
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