Carbopalladation of nitriles: synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of omega-(2-iodoaryl)alkanenitriles and related compounds |
| |
Authors: | Pletnev Alexandre A Larock Richard C |
| |
Institution: | Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. |
| |
Abstract: | An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|