一种新型羟基葫芦[6]脲气相色谱固定相性能的研究

本文首次成功地制备和利用羟基葫芦6]脲((HO)12CB6])作填充柱气相色谱固定相。研究表明，羟基葫芦6]脲固定相(PSP)具有较宽的操作柱温、高度的化学和热稳定性，对多种类型的化合物展示较高的色谱分离选择性，这包括烷烃、芳烃、醇类、酯类、酮类和胺类等多种化合物。新柱对一些二取代苯环芳族位置异构体有较强的分离能力。实验发现，羟基葫芦6]脲固定相对日用花露水中复杂的挥发性成分有高效快速分离能力。同时，初步探讨了新固定相的色谱分离机理，发现羟基葫芦6]脲对溶质的部分包结作用，而不是完全包结作用，有利于提高其色谱分离选择性和柱效。此外，在极速程序升温色谱中，该固定相低流失基线漂移小，有利于实现宽沸点范围复杂样品的快速气相色谱分离分析。

Studies on Chromatographic Properties of Perhydroxycucurbit[6]uril as a New Type of Gas Chromatographic Column Packing Material

Perhydroxycucurbit6]uril {(HO)₁₂CB6]} has been used successfully as a stationary phase for packed column gas chromatography for the first time. Perhydroxycucurbit6]uril stationary phase (PSP) exhibited wide operational temperature, outstanding thermostability and good selectivities to various organic compounds, such as alkanes, aromatic hydrocarbons, alcohols, esters, ketones, amines, etc. It was also found that some positional isomers, such as disubstituted benzenes could be well separated on this column. PSP has excel1ent separation abilities to some complicate samples, for example, commercial toilet water. Some mechanism of the new packing for GC‐separation was preliminarily discussed. It was observed that the partial inclusion complexation of PSP with analytes could improve separation selectivity and column efficiency, instead of complete inclusion. Moreover, PSP exhibited low baseline shift even at dramatically programmed temperature for complicate samples covering a wide boiling point range so as to fast assay.