An efficient 1,2-chelation-controlled reduction of protected hydroxy ketones via Red-Al |
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| Authors: | Bajwa Naval Jennings Michael P |
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| Affiliation: | Department of Chemistry, 250 Hackberry Lane, The University of Alabama, Tuscaloosa, Alabama 35487-0336, USA. |
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| Abstract: | In this paper, we have demonstrated that Red-Al is an efficient chelation-controlled reducing reagent for acyclic acetal (i.e., MOM, MEM, SEM, and BOM) protected alpha-hydroxy ketones. Typically, diastereomeric ratios (dr) ranged from 5 to 20:1 for the 1,2- anti-diols in good to excellent yields. |
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