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| A Novel Conformation Investigation on Newly Synthesized Compound of Diethyl Puerarin-7-yl Phosphate | |
| 引用本文： | 袁金伟,陈晓岚,屈凌波,唐明生,梁瑞玲,赵玉芬. A Novel Conformation Investigation on Newly Synthesized Compound of Diethyl Puerarin-7-yl Phosphate[J]. 结构化学, 2006, 25(1): 78-84 |
| 作者姓名： | 袁金伟 陈晓岚 屈凌波 唐明生 梁瑞玲 赵玉芬 |
| 作者单位： | Department of Chemistry Key Laboratory of Chemical Biology Zhengzhou University Zhengzhou 450052 China，Department of Chemistry Key Laboratory of Chemical Biology Zhengzhou University Zhengzhou 450052 China，Department of Chemistry Key Laboratory of Chemical Biology Zhengzhou University Zhengzhou 450052 China，Anyang Normal College Henan Province Anyang 455002 China，Department of Chemistry Key Laboratory of Chemical Biology Zhengzhou University Zhengzhou 450052 China，Department of Chemistry Key Laboratory of Chemical Biology Zhengzhou University Zhengzhou 450052 China，Department of Chemistry Key Laboratory of Chemical Biology Zhengzhou University Zhengzhou 450052 China，Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry School of Life Sciences and Engineering Tsinghua University Beijing 100084 China |
| 摘 要： | 1INTRODUCTION Puerarin(4?,7-dihydroxy-8-β-D-glucosylisoflavo ne),whose chemical structure is shown in Fig.1,is a C-glycoside compound.It is present in a large amount of active components of Puerariae radix,a com-monly used Chinese herb,which exerts sedative and antipyretic actions and is often used to treat influ-enza,wrist stiffness and headache[1].A number of investigations were carried out internationally to iden-tify the physiological activities of puerarin such as antiproliferative… |
| 关 键 词： | 二甲基葛根素磷酸盐 合成方法 葛根素 化学计算 结构研究 |
A Novel Conformation Investigation on Newly Synthesized Compound of Diethyl Puerarin-7-yl Phosphate |
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| YUAN Jin-Wei,CHEN Xiao-Lan,QU Ling-Bo,TANG Ming-Sheng,LIANG Rui-Ling,ZHAO Yu-Fen. A Novel Conformation Investigation on Newly Synthesized Compound of Diethyl Puerarin-7-yl Phosphate[J]. Chinese Journal of Structural Chemistry, 2006, 25(1): 78-84 | |
| Authors: | YUAN Jin-Wei CHEN Xiao-Lan QU Ling-Bo TANG Ming-Sheng LIANG Rui-Ling ZHAO Yu-Fen |
| Affiliation: | 1. Department of Chemistry, Key Laboratory of Chemical Biology, Zhengzhou University, Zhengzhou 450052, China 2. Department of Chemistry, Key Laboratory of Chemical Biology, Zhengzhou University, Zhengzhou 450052, China;Anyang Normal College, Henan Province, Anyang 455002, China 3. Department of Chemistry, Key Laboratory of Chemical Biology, Zhengzhou University, Zhengzhou 450052, China;Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering,Tsinghua University, Beijing 100084, China |
| Abstract: | A novel compound, diethyl puerarin-7-yl phosphate, was synthesized through a simplified Atheron-Todd reaction for the first time. The structure of this compound was elucidated by IR, ESI-MS and NMR. Two conformations of the compound were testified by 2D NMR (HSQC and HMBC) and dynamic NMR. Furthermore, we carried out the conformational analysis using chemical calculation by the Gaussian 03. Finally, we obtained two preferred conformations and energy values. |
| Keywords: | puerarin synthesis chemical calculation conformation group |
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