A new halopropargylation of alkynes promoted by boron trihalides. highly stereo- and regioselective syntheses of substituted (Z)-1-halo-1,4-enyne derivatives |
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| Authors: | Kabalka George W Wu Zhongzhi Ju Yuhong |
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| Institution: | Department of Chemistry, The University of Tennessee, Knoxville, Tennessee 37006-1600, USA. kabalka@utk.edu |
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| Abstract: | reaction: see text] A new halopropargylation of alkynes promoted by boron trihalides has been developed. Reactions of (Z)-2-halo-1-vinylboron dihalides (generated in situ via reaction of alkynes with boron trihalides) with lithium propargyloxides in CH(2)Cl(2) at room temperature produce the corresponding (Z)-1-halo-1,4-enynes in modest to good yields. |
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