Friedel-Crafts and modified Vorbrüggen ribosylation. A short synthesis of aryl and heteroaryl-C-nucleosides |
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| Authors: | Marie Spadafora |
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| Affiliation: | Laboratoire de Chimie des Molécules Bioactives et des Arômes UMR CNRS-UNSA 6001, Institut de Chimie de Nice, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France |
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| Abstract: | A direct coupling of aryl donor and tetra-O-acetylribose in the presence of Lewis acid led to β-C-nucleosides in good yields. In contrast, for deactivated electron-poor aromatics, a modified Vorbrüggen ribosylation reaction was investigated and successfully applied in the case of 2-trimethylsilyl-thiazole. |
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| Keywords: | Friedel-Crafts ribosylation Modified Vorbrü ggen reaction C-Nucleosides |
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