Iodine-catalyzed N-alkylation of tosylhydrazones with benzylic alcohols |
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Authors: | P Theerthagiri A Lalitha |
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Institution: | 1. Department of Chemistry, Periyar University, Salem, 636 011, Tamil Nadu, India
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Abstract: | A new and highly efficient method for the C–N bond formation using molecular iodine-catalyzed N-alkylation reaction of tosylhydrazones with benzylic/benzhydryl alcohols at room temperature in methylene chloride is described. A variety of tosylhydrazones reacted readily with various substituted benzylic alcohols in presence of 20 mol % iodine under mild reaction conditions to produce the corresponding biologically active N-alkylated compounds in good to excellent yields. |
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