Interplay between amphiphilic peptides and nanoparticles for selective membrane destabilization and antimicrobial effects |
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| Affiliation: | 1. Department of Pharmacy, University of Copenhagen, DK-2100, Copenhagen, Denmark;2. Physical Chemistry 1, University of Lund, S-221 00, Lund, Sweden;1. School of Resources & Environment, Northeast Agricultural University, Harbin 150030, China;2. College of Science, Northeast Agricultural University, Harbin 150030, China;1. National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China;2. School of Material Science and Engineering, South China University of Technology, Guangzhou 510640, PR China;1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;2. Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China;1. Department of Biophysics, Bose Institute, Kolkata, 700054, India;2. School of Nanoscience and Technology, IIT Kharagpur, Kharagpur, 721302, India;3. Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L3G1, Canada;4. Department of Biotechnology, IIT Madras, Chennai, 600036, India;5. Division of Molecular Medicine, Bose Institute, Kolkata, 700054, India;6. Department of Physics, IIT Kharagpur, Kharagpur, 721302, India;7. Department of Pharmacy, Uppsala University, SE-75232, Uppsala, Sweden;8. Department of Pharmacy, University of Copenhagen, DK-2100, Copenhagen, Denmark;1. NMR Research Centre, Indian Institute of Science, Bangalore 560012, India;2. Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India;3. Department of Biophysics, Bose Institute, Kolkata 700054, India;4. Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore 560012, India |
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| Abstract: | As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity, and amphiphilicity. Inorganic nanoparticles may provide opportunities for controlling peptide release, reducing infection-related AMP degradation, or increasing bioavailability. Numerous such nanomaterials display potent and triggerable antimicrobial effects on their own. When combined with AMPs, combinatorial and synergistic effects in relation to the behavior of such mixed systems as antimicrobials have been observed. The mechanistic origin of these effects are poorly understood that at present, however, precluding rational design of mixed nanoparticle antimicrobials/AMPs and nanoparticulate delivery systems for AMPs. Here, the area of membrane interactions and antimicrobial effects of inorganic nanomaterials are briefly outlined, in combination with AMPs. |
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| Keywords: | Antimicrobial peptide Bilayer Drug delivery Membrane Nanoparticle |
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