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Synthesis and anti-HIV activity of sulfated astragalus polysaccharide |
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| Authors: | Guo-Guang Liu Gereltu Borjihan Huricha Baigude Hedeki Nakashima Toshiyuki Uryu |
| Affiliation: | 1. Institute of Macromolecular Chemistry and Mongolian Medicines, Inner Mongolia University, Hohhot 010021, People's Republic of China;2. Department of Microbiology and Immunology, School of Dentistry, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshimashi, 890-8544, Japan;3. Future Materials Research, Teikyo University of Science and Technology, Center, 2525 Yatsusawa, Uenohara, Yamanashi, Japan |
| Abstract: | Sulfated astragalus polysaccharide (sulfated astragalan, SA) was prepared by chemical modification of astragalus polysaccharide abstracted from an astragalus menbranceus used as a Mongolia herbal medicine. Anti-HIV activity of SA was assayed in vitro and the results indicated that the SA showing high anti-HIV activity and lower cytotoxity. Sulfation of astragalan was carried out by using sulfur trioxide-pyridine complex in a mixture of dimethylsulfoxide (DMSO) to give sulfated astragalan with degree of substitution (DS) of 1.14–1.20 and a number average molecular weight (Mn) of 1.27–1.46 × 104. Copyright © 2003 John Wiley & Sons, Ltd. |
| Keywords: | polysaccharides sulfate anti-HIV biological applications of polymers synthesis |