Enzyme encapsulation in nanostructured self-assembled structures: Toward biofunctional supramolecular assemblies |
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| Institution: | 1. Physical Chemistry, Department of Chemistry, Lund University, P.O.Box 124, 22100 Lund, Sweden;2. NanoLund, Lund University, PO Box 118, 22100 Lund, Sweden;3. Department of Chemical and Geological Sciences, University of Cagliari and Center for NanoBiotechnologies in Sardinia (CNBS), Cittadella Universitaria, S.S. 554 Bivio Sestu, 09042 Monserrato, Cagliari, Italy;4. Consorzio Interuniversitario per Lo Sviluppo Dei Sistemi a Grande Interfase (CSGI), Sesto Fiorentino (FI), Unità Operativa Univ. Cagliari, Italy;5. Camurus AB, Ideon Science Park, Gamma Building, Solvegatan 41, 22379 Lund, Sweden;6. Biomedical Science, Faculty of Health and Society, Malmö University, 20506 Malmö, Sweden;7. Vilnius University, Life Sciences Center, Saulėtekio Av. 7, LT- 10257 Vilnius, Lithuania;8. LINXS - Lund Institute of Advanced Neutron and X-ray Science, IDEON Building: Delta 5, Scheelevägen 19, 22370 Lund, Sweden;1. UCD Complex & Adaptive Systems Laboratory, UCD School of Computer Science and Informatics, University College Dublin, Ireland;2. Sastrion Sp. z o. o., Poland;1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, Australia;2. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, 381 Royal Parade, Parkville, VIC, Australia;1. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark;2. Laboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland;1. Faculty of Chemistry, University of Warsaw, Pasteura 1, PL 02-093 Warsaw, Poland;2. Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland |
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| Abstract: | Enzymes have come into use for many new applications outside their natural biological environment, taking advantage of their high efficiency and selectivity as biocatalysts. Such new application often requires encapsulation to preserve the structure and activity of the enzyme, but also to regulate and control the activity. Here, we will discuss two types of encapsulation, soft matrices consisting of polar lipid liquid crystals and hard ordered mesoporous silica matrices. For both types of matrices, the challenge is to control the pore size of the matrices and the interaction with the matrix interface. Here, the polar lipid liquid crystals offer larger flexibility than silica, but on the other hand, it is considerably more sensitive to the environment. |
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| Keywords: | Enzyme encapsulation Enzyme activity Pore size Polar lipid liquid crystals Cubic phase Mesoporous silica |
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