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Influence of polymeric coating on capillary electrophoresis of iron oxide nanoparticles |
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| Authors: | Hadi Baharifar Ali Reza Fakhari Hakimeh Ziyadi Mohammad Ali Oghabian Amir Amani Reza Faridi-Majidi |
| Affiliation: | 1. Department of Medical Nanotechnology, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Tehran, Iran 3. Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran 4. Research Center of Science and Technology in Medicine (RCSTIM), Imam Khomeini Hospital Complex, Keshavarz Blvd, Tehran, Iran |
| Abstract: | In this work, electrophoresis was successfully used to separate three different polymer-coated magnetic iron oxide nanoparticles with similar sizes (nominally 50 nm) using high-pH borate buffer system. The coating polymers were dextran, polyethylene glycol, or carboxymethyl dextran. The results showed that the migration time of carboxymethyl dextran coated nanoparticles is the longest due to relatively more negative surface charges. Investigation of the effects of buffer concentration, pH, electric field strength and the capillary temperature, on electrophoretic properties of samples was also carried out. The results showed that pH, electric field strength and the capillary temperature had indirect relations with both of the migration time and the separation resolution of three different polymer-coated nanoparticles while the buffer concentration had a direct relation. |
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