| Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors |
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| 引用本文： | Xian Chao CHENG Xin Yong LIU Wen Fang XU. Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors[J]. 中国化学快报, 2006, 17(10): 1317-1320 |
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| 作者姓名： | Xian Chao CHENG Xin Yong LIU Wen Fang XU |
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| 作者单位： | Xian Chao CHENG，Xin Yong LIU，Wen Fang XU Institute of Medicinal Chemistry，School of Pharmaceutical Science，Shandong University，Jinan 250012 |
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| 摘 要： | Ligustrazine (lig; tetramethylpyrazine, TMP; Figure 1) is one of major efficient components from Chinese traditional medicine herb Ligusticum Chuanxiong Hort, which is currently widely used in China for the treatment of coronary atherosclerotic cardiovasc…
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| 关 键 词： | 合成 川芎嗪 衍生物 抗血小板聚集药 |
| 收稿时间： | 2006-05-17 |
Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors |
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| Xian Chao CHENG,Xin Yong LIU,Wen Fang XU. Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors[J]. Chinese Chemical Letters, 2006, 17(10): 1317-1320 |
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| Authors: | Xian Chao CHENG Xin Yong LIU Wen Fang XU |
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| Abstract: | A series of novel ligustrazine derivatives were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, 1H NMR and ESI-MS. The preliminary antiplatelet aggregation screening results demonstrated that the compounds 7a, 7b and 7c showed higher potency than ligustrazine. |
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| Keywords: | Synthesis ligustrazine derivatives platelet aggregation inhibitors. |
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