| Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors |
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| 作者姓名： | Xian Chao CHENG Xin Yong LIU Wen Fang XU |
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| 作者单位： | Xian Chao CHENG，Xin Yong LIU，Wen Fang XU Institute of Medicinal Chemistry，School of Pharmaceutical Science，Shandong University，Jinan 250012 |
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| 摘 要： | Ligustrazine (lig; tetramethylpyrazine, TMP; Figure 1) is one of major efficient components from Chinese traditional medicine herb Ligusticum Chuanxiong Hort, which is currently widely used in China for the treatment of coronary atherosclerotic cardiovasc…
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| 关 键 词： | 合成 川芎嗪 衍生物 抗血小板聚集药 |
| 收稿时间： | 05 17 2006 12:00AM |
Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors |
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| Xian Chao CHENG Xin Yong LIU Wen Fang XU.Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors[J].Chinese Chemical Letters,2006,17(10):1317-1320. |
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| Authors: | Xian Chao CHENG Xin Yong LIU Wen Fang XU |
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| Abstract: | A series of novel ligustrazine derivatives were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, 1H NMR and ESI-MS. The preliminary antiplatelet aggregation screening results demonstrated that the compounds 7a, 7b and 7c showed higher potency than ligustrazine. |
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| Keywords: | Synthesis ligustrazine derivatives platelet aggregation inhibitors |
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