| 药物核磁共振定量分析参数的研究 |
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| 引用本文： | 张友杰,刘小鹏. 药物核磁共振定量分析参数的研究[J]. 波谱学杂志, 2007, 24(3): 289-295 |
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| 作者姓名： | 张友杰 刘小鹏 |
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| 作者单位： | 1. 武汉生物工程学院 分析测试中心，湖北 武汉 430415; 2. 华中师范大学 分析测试中心，湖北 武汉 430079 |
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| 基金项目： | 国家自然科学基金，湖北省科研项目 |
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| 摘 要： | 药物核磁共振定量分析已见诸多篇报道. 英、美、欧药典中都先后引入了核磁共振分析方法.本文对药物核磁共振定量分析的参数作了较为详尽的研究，提出了选择定量特征峰的新标准.经维生素C实际样品测定其精密度优于1%，结果满意.
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| 关 键 词： | 核磁共振 定量分析 药物 核磁共振参数 维生素C
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| 文章编号： | 1000-4556（2007）03-0289-07 |
| 收稿时间： | 2006-12-11 |
| 修稿时间： | 2006-12-112007-01-15 |
Studies of NMR Acquisition Parameters for Quantitative Analysis of Drugs |
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| ZHANG You-jie,LIU Xiao-peng. Studies of NMR Acquisition Parameters for Quantitative Analysis of Drugs[J]. Chinese Journal of Magnetic Resonance, 2007, 24(3): 289-295 |
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| Authors: | ZHANG You-jie LIU Xiao-peng |
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| Affiliation: | 1.The Center for Analysis and Testing, Wuhan Bioengineering Institute, Wuhan 430415; 2.The Center for Analysis and Testing, Central China Normal University, Wuhan 430079 |
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| Abstract: | The principles underlying selection of NMR acquisition parameters (i.e., relaxation delay time, pulse width and number of transient etc.) for quantitative analysis of drugs were discussed in detail. Some requirements on selecting appropriate peaks for quantitative analysis were proposed. We showed that the methyl peak is not suitable for quantitative analysis because it often has long relaxation time. With the principles discussed, the content of vitamin C determined by quantitative NMR analysis was found to have relative standard deviation less than 1%. |
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| Keywords: | nuclear magnetic resonance quantitative analysis drug acquisition parameter vitamin C |
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