General Olefin Synthesis by the Palladium‐Catalyzed Heck Reaction of Amides: Sterically Controlled Chemoselective N?C Activation |
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Authors: | Guangrong Meng Michal Szostak |
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Abstract: | Metal‐catalyzed reactions of amides proceeding via metal insertion into the N CO bond are severely underdeveloped due to resonance stabilization of the amide bond. Herein we report the first Heck reaction of amides proceeding via highly chemoselective N CO cleavage catalyzed by Pd0 utilizing amide bond ground‐state destabilization. Conceptually, this transformation provides access to a myriad of metal‐catalyzed transformations of amides via metal insertion/decarbonylation. |
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Keywords: | Amidbindungen Basefreie Heck‐Reaktion Heck‐Reaktion N‐C‐Aktivierung |
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