Application of a C?C Bond‐Forming Conjugate Addition Reaction in Asymmetric Dearomatization of β‐Naphthols |
| |
Authors: | Dongxu Yang Linqing Wang Ming Kai Dan Li Xiaojun Yao Rui Wang |
| |
Abstract: | A C C bond‐forming conjugate reaction was successfully applied to the enantioselective dearomatization of β‐naphthols. A C(sp2) C(sp3) bond is formed by using propargylic ketones as reactive partners. Good to excellent Z/E ratios and ee values were obtained by employing an in situ generated magnesium catalyst. Further transformations of the Z‐configured C C double bond in the products were achieved under mild reaction conditions. Moreover, the stereocontrolling element of this magnesium‐catalyzed dearomatization reaction was explored by computational chemistry. |
| |
Keywords: | Arene Aromatizitä t Dichtefunktionalrechnungen Magnesium Naphthole |
|