Two new isatin derivatives: 1‐benzyl‐4,5,6‐trimethoxyindoline‐2,3‐dione and 1‐benzyl‐5‐fluoroindoline‐2,3‐dione |
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Authors: | N Sharmila T V Sundar G Satish A Ilangovan P Venkatesan |
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Abstract: | Isatin (1H‐indole‐2,3‐dione) derivatives represent synthetically useful substrates which can be used to prepare a broad range of heterocyclic compounds. In the title compounds, C18H17NO5, (I), and C15H10FNO2, (II), the isatin ring systems are planar and form a dihedral angle of 73.04 (7)° in (I) and 76.82 (11)° in (II) with the benzyl groups. The bicyclic scaffolds in both compounds are almost superimposable, with an r.m.s. deviation of 0.061 Å. The crystal structures of both derivatives are stabilized by C—H...O interactions. These contacts generate an R12(7) ring motif in (I) and a C(7) chain motif in (II). |
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Keywords: | isatin Schiff bases crystal packing crystal structure C— H O interactions bioactive compounds C— H functionalization 1H‐indole‐2 3‐dione |
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