Sulfated Triterpenes from Lemon Balm |
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| Authors: | Mudasir A. Tantry Gulzar A. Bhat Ahmed Idris Javid A. Dar Suliman Yousef Al Omar Khalid Z. Masoodi Bashir A. Ganai Azra N. Kamili Abdul S. Shawl |
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| Affiliation: | 1. Phytochemistry Laboratories, Centre of Research for Development, University of Kashmir, Srinagar, Kashmir 190006, India (phone: +91‐194‐2420078;2. fax: +91‐194‐2421357);3. Department of Biochemistry, University of Kashmir, Srinagar, Kashmir 190006, India;4. Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, USA;5. Central Laboratory, College of Science, King Saud University, Riyadh 11451, KSA;6. Department of Urology Research Laboratories, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA;7. Natural Products Chemistry Division, CSIR‐Indian Institute of Integrative Medicine, Srinagar, Kashmir 190005, India |
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| Abstract: | The hydroalcoholic (EtOH/H2O) extract of matured leaf margins of lemon balm (Melissa officinalis L.) afforded a new 3,23‐disulfate of 2α,3β‐23,29‐tetrahydroxyolean‐12‐en‐28‐oic acid 28‐O‐β‐D ‐glucopyranoside ( 1 ) and a new 23‐monosulfate of 2α,23‐dihydroxyurs‐12‐en‐28‐oic acid 3‐O‐β‐D ‐glucopyranoside ( 2 ), along with six known compounds, i.e., 23‐monosulfate of 2α,3β,19α,23‐tetrahydroxyurs‐12‐ene‐28‐oic acid 28‐O‐β‐D ‐glucopyranoside ( 3 ), 3,5,6‐trihydroxydehydro‐α‐ionol 9‐O‐β‐D ‐glucopyranoside ( 4 ), quadranoside III ( 5 ), rosmarinic acid ( 6 ), caffeic acid ( 7 ), and luteolin ( 8 ). All the isolated compounds were evaluated for their antioxidant, antimicrobial, antimalarial, and cytotoxic activities. Only rosmarinic acid exhibited substantial antioxidant and antimicrobial activities, whereas sulfated terpenes showed considerably lower or no antimicrobial activity. |
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| Keywords: | Melissa officinalis Lemon balm Triterpenes Antioxidant activity Antimicrobial activity Antimalarial activity Cytotoxic activity |
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