Organic and Biomolecular Chemistry Division, CSIR‐Indian Institute of Chemical Technology, Tarnaka, Hyderabad‐500 007, India, (phone/fax: +91‐4‐27193003)
Abstract:
The stereoselective formal synthesis of (?)‐cyclaradine from the inexpensively available starting material L ‐glutamic acid is described, using Eschenmoser's reagent, and applying Luche reduction, Grignard reaction, and ring closing metathesis (RCM) as the key steps.